It07:Terbutaline Sulphate

2007-10-30T15:18:32Z

Mr406:

{{Drug-Box |
| Box_Name = Terbutaline Sulphate
| ImageFile = Terbutaline_sulphate.png
| IUPACName = tert-butyl-[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]azanium sulfate
| OtherName = Bricanyl
| CAS_No = {{{23031-32-5}}}
| ATC_Code = [http://www.whocc.no/atcddd/indexdatabase/index.php?query=R03AC03 R03AC03][http://www.whocc.no/atcddd/indexdatabase/index.php?query=R03CC03 R03CC03]
| PubChem = 36120
| SMILES = CC(C)(C)[NH2+]CC(C1=CC(=CC(=C1)O)O)O.CC(C)(C)
[NH2+]CC(C1=CC(=CC(=C1)O)O)O.[O-]S(=O)(=O)[O-
| Formula =(C<sub>12</sub>H<sub>20</sub>NO<sub>3</sub>)<sub>2</sub> SO<sub>4</sub>
| MolarMass = 548.6468
| Metabolism = GI tract (oral), liver; CYP450: unknown
| Half_life = urine 90% (60% unchanged), bile/faeces; Half-life: 3-4h
| Pregnancy_cat = B
| Legal_status = [http://en.wikipedia.org/wiki/Prescription_drug POM]
| Routes = SQ, Oral, Inhaled
}}
<noinclude>
==Terbutaline Sulphate==
==Structure==
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==Crystal Structure==
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Terbutaline sulphate belongs to a class of drugs known as [http://en.wikipedia.org/wiki/Beta2-adrenergic_receptor_agonist short acting beta 2 agonists]. It is a [http://en.wikipedia.org/wiki/Bronchodilator bronchodilator] These drugs work by acting on the lungs' beta 2 receptors. Stimulation of these recpetors cause the relaxation of muscles in the airway, thus allowing the opening of the airway. Terbutaline sulphate is used in the treatment of conditions that cause the narrowing of airways such as [http://en.wikipedia.org/wiki/Asthma asthma], [http://en.wikipedia.org/wiki/Bronchitis bronchitis] and [http://en.wikipedia.org/wiki/Emphysema emphysema]. Terbutaline sulphate is mainly administered as an inhaler, where the drug can directly get to the lungs. It can also be taken in tablet form if the inhaler is being used frequently to ease shortness of breath. The tablets can be taken regularly to help keep the airways constantly open and reduce inhaler usage. However the inhaler has the advantage of reducing the chance of side effects occuring in other body parts, as the quantity of the drug absorbed by the blood via inhalation is smaller than the quantity taken orally.<ref>http://www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100002557.html</ref>

==Conditions where the drug is used==
[http://en.wikipedia.org/wiki/COPD Chronic obstructive pulmonary disease] (COPD)

[http://en.wikipedia.org/wiki/Bronchospasm Bronchospasm] (narrowing of the airways) in other lung conditions (e.g. bronchitis and emphysema)

Asthma <ref>http://www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100002557.html</ref>

==Side Effects==
Chest discomfort

Breathing difficulty

Dizziness

Drowsiness

Fast, irregular heartbeat

Headache

Increased heart rate

Nausea

Sweating

Tremors

Weakness <ref>http://www.drugs.com/pdr/terbutaline-sulfate.html</ref>

==Synthesis==
To synthesise terbutaline sulphate, first terbutaline needs to be formed from the parent [http://en.wikipedia.org/wiki/Cyanohydrin cyanohydrin]. This done via a [http://en.wikipedia.org/wiki/Ritter_reaction Ritter reaction] to convert the [http://en.wikipedia.org/wiki/Nitrile nitrile] group into an N-alkyl [http://en.wikipedia.org/wiki/Amide amide]. <ref>Synthesis of the Adrenergic Bronchodilators (R)-Terbutaline and (R)-Salbutamol from (R)-Cyanohydrins1
Effenberger, F.; Jager, J.
J. Org. Chem.; (Article); 1997; 62(12); 3867-3873. DOI: 10.1021/jo970032d </ref>

When the N-alkyl amide has been made; treat with [http://en.wikipedia.org/wiki/Sulphuric_acid sulphuric acid] to make terbutaline sulphate.

[[Image:Synthesis.png|center|350px|synthesis of terbutaline sulphate]]

[[Image:Bricanyl_Terbutaline_sulphate.JPG|center|350px|Bricanyl terbutaline sulphate inhaler]]

==References==

<references/>

It07:Terbutaline Sulphate

2007-10-30T15:16:59Z

Mr406:

{{Drug-Box |
| Box_Name = Terbutaline Sulphate
| ImageFile = Terbutaline_sulphate.png
| IUPACName = tert-butyl-[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]azanium sulfate
| OtherName = Bricanyl
| CAS_No = {{{23031-32-5}}}
| ATC_Code = [http://www.whocc.no/atcddd/indexdatabase/index.php?query=R03AC03 R03AC03][http://www.whocc.no/atcddd/indexdatabase/index.php?query=R03CC03 R03CC03]
| PubChem = 36120
| SMILES = CC(C)(C)[NH2+]CC(C1=CC(=CC(=C1)O)O)O.CC(C)(C)
[NH2+]CC(C1=CC(=CC(=C1)O)O)O.[O-]S(=O)(=O)[O-
| Formula =(C<sub>12</sub>H<sub>20</sub>NO<sub>3</sub>)<sub>2</sub> SO<sub>4</sub>
| MolarMass = 548.6468
| Metabolism = GI tract (oral), liver; CYP450: unknown
| Half_life = urine 90% (60% unchanged), bile/faeces; Half-life: 3-4h
| Pregnancy_cat = B
| Legal_status = [http://en.wikipedia.org/wiki/Prescription_drug POM]
| Routes = SQ, Oral, Inhaled
}}
<noinclude>
==Terbutaline Sulphate==
==Structure==
<jmol>
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<title>mo_terbutaline_sulphate.pdb</title><color>black</color>
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==Crystal Structure==
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Terbutaline sulphate belongs to a class of drugs known as [http://en.wikipedia.org/wiki/Beta2-adrenergic_receptor_agonist short acting beta 2 agonists]. It is a [http://en.wikipedia.org/wiki/Bronchodilator bronchodilator] These drugs work by acting on the lungs' beta 2 receptors. Stimulation of these recpetors cause the relaxation of muscles in the airway, thus allowing the opening of the airway. Terbutaline sulphate is used in the treatment of conditions that cause the narrowing of airways such as [http://en.wikipedia.org/wiki/Asthma asthma], [http://en.wikipedia.org/wiki/Bronchitis bronchitis] and [http://en.wikipedia.org/wiki/Emphysema emphysema]. Terbutaline sulphate is mainly administered as an inhaler, where the drug can directly get to the lungs. It can also be taken in tablet form if the inhaler is being used frequently to ease shortness of breath. The tablets can be taken regularly to help keep the airways constantly open and reduce inhaler usage. However the inhaler has the advantage of reducing the chance of side effects occuring in other body parts, as the quantity of the drug absorbed by the blood via inhalation is smaller than the quantity taken orally.<ref>http://www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100002557.html</ref>

==Conditions where the drug is used==
[http://en.wikipedia.org/wiki/COPD Chronic obstructive pulmonary disease] (COPD)

[http://en.wikipedia.org/wiki/Bronchospasm Bronchospasm] (narrowing of the airways) in other lung conditions (e.g. bronchitis and emphysema)

Asthma <ref>http://www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100002557.html</ref>

==Side Effects==
Chest discomfort

Breathing difficulty

Dizziness

Drowsiness

Fast, irregular heartbeat

Headache

Increased heart rate

Nausea

Sweating

Tremors

Weakness <ref>http://www.drugs.com/pdr/terbutaline-sulfate.html</ref>

==Synthesis==
To synthesise terbutaline sulphate, first terbutaline needs to be formed from the parent [http://en.wikipedia.org/wiki/Cyanohydrin cyanohydrin]. This done via a [http://en.wikipedia.org/wiki/Ritter_reaction Ritter reaction] to convert the [http://en.wikipedia.org/wiki/Nitrile nitrile] group into an N-alkyl [http://en.wikipedia.org/wiki/Amide amide]. <ref>Synthesis of the Adrenergic Bronchodilators (R)-Terbutaline and (R)-Salbutamol from (R)-Cyanohydrins1
Effenberger, F.; Jager, J.
J. Org. Chem.; (Article); 1997; 62(12); 3867-3873. DOI: 10.1021/jo970032d </ref>

When the N-alkyl amide has been made; treat with [http://en.wikipedia.org/wiki/Sulphuric_acid sulphuric acid] to make terbutaline sulphate.

[[Image:Synthesis.png|center|350px|synthesis of terbutaline sulphate]]

[[Image:Bricanyl_Terbutaline_sulphate.JPG|center|350px|Bricanyl terbutaline sulphate inhaler]]

==References==

<references/>

It07:Terbutaline Sulphate

2007-10-30T15:15:46Z

Mr406:

{{Drug-Box |
| Box_Name = Terbutaline Sulphate
| ImageFile = Terbutaline_sulphate.png
| IUPACName = tert-butyl-[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]azanium sulfate
| OtherName = Bricanyl
| CAS_No = {{{23031-32-5}}}
| ATC_Code = [http://www.whocc.no/atcddd/indexdatabase/index.php?query=R03AC03 R03AC03][http://www.whocc.no/atcddd/indexdatabase/index.php?query=R03CC03 R03CC03]
| PubChem = 36120
| SMILES = CC(C)(C)[NH2+]CC(C1=CC(=CC(=C1)O)O)O.CC(C)(C)
[NH2+]CC(C1=CC(=CC(=C1)O)O)O.[O-]S(=O)(=O)[O-
| Formula =(C<sub>12</sub>H<sub>20</sub>NO<sub>3</sub>)<sub>2</sub> SO<sub>4</sub>
| MolarMass = 548.6468
| Metabolism = GI tract (oral), liver; CYP450: unknown
| Half_life = urine 90% (60% unchanged), bile/faeces; Half-life: 3-4h
| Pregnancy_cat = B
| Legal_status = [http://en.wikipedia.org/wiki/Prescription_drug POM]
| Routes = SQ, Oral, Inhaled
}}
<noinclude>
==Terbutaline Sulphate==
==Structure==
<jmol>
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Terbutaline sulphate belongs to a class of drugs known as [http://en.wikipedia.org/wiki/Beta2-adrenergic_receptor_agonist short acting beta 2 agonists]. It is a [http://en.wikipedia.org/wiki/Bronchodilator bronchodilator] These drugs work by acting on the lungs' beta 2 receptors. Stimulation of these recpetors cause the relaxation of muscles in the airway, thus allowing the opening of the airway. Terbutaline sulphate is used in the treatment of conditions that cause the narrowing of airways such as [http://en.wikipedia.org/wiki/Asthma asthma], [http://en.wikipedia.org/wiki/Bronchitis bronchitis] and [http://en.wikipedia.org/wiki/Emphysema emphysema]. Terbutaline sulphate is mainly administered as an inhaler, where the drug can directly get to the lungs. It can also be taken in tablet form if the inhaler is being used frequently to ease shortness of breath. The tablets can be taken regularly to help keep the airways constantly open and reduce inhaler usage. However the inhaler has the advantage of reducing the chance of side effects occuring in other body parts, as the quantity of the drug absorbed by the blood via inhalation is smaller than the quantity taken orally.<ref>http://www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100002557.html</ref>

==Conditions where the drug is used==
[http://en.wikipedia.org/wiki/COPD Chronic obstructive pulmonary disease] (COPD)

[http://en.wikipedia.org/wiki/Bronchospasm Bronchospasm] (narrowing of the airways) in other lung conditions (e.g. bronchitis and emphysema)

Asthma <ref>http://www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100002557.html</ref>

==Side Effects==
Chest discomfort

Breathing difficulty

Dizziness

Drowsiness

Fast, irregular heartbeat

Headache

Increased heart rate

Nausea

Sweating

Tremors

Weakness <ref>http://www.drugs.com/pdr/terbutaline-sulfate.html</ref>

==Synthesis==
To synthesise terbutaline sulphate, first terbutaline needs to be formed from the parent [http://en.wikipedia.org/wiki/Cyanohydrin cyanohydrin]. This done via a [http://en.wikipedia.org/wiki/Ritter_reaction Ritter reaction] to convert the [http://en.wikipedia.org/wiki/Nitrile nitrile] group into an N-alkyl [http://en.wikipedia.org/wiki/Amide amide]. <ref>Synthesis of the Adrenergic Bronchodilators (R)-Terbutaline and (R)-Salbutamol from (R)-Cyanohydrins1
Effenberger, F.; Jager, J.
J. Org. Chem.; (Article); 1997; 62(12); 3867-3873. DOI: 10.1021/jo970032d </ref>

When the N-alkyl amide has been made; treat with [http://en.wikipedia.org/wiki/Sulphuric_acid sulphuric acid] to make terbutaline sulphate.

[[Image:Synthesis.png|center|350px|synthesis of terbutaline sulphate]]

[[Image:Bricanyl_Terbutaline_sulphate.JPG|center|350px|Bricanyl terbutaline sulphate inhaler]]

==References==

<references/>

It07:Terbutaline Sulphate

==Terbutaline Sulphate==
{{Drug-Box |
| Box_Name = Terbutaline Sulphate
| ImageFile = Terbutaline_sulphate.png
| IUPACName = tert-butyl-[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]azanium sulfate
| OtherName = Bricanyl
| CAS_No = {{{23031-32-5}}}
| ATC_Code = [http://www.whocc.no/atcddd/indexdatabase/index.php?query=R03AC03 R03AC03][http://www.whocc.no/atcddd/indexdatabase/index.php?query=R03CC03 R03CC03]
| PubChem = 36120
| SMILES = CC(C)(C)[NH2+]CC(C1=CC(=CC(=C1)O)O)O.CC(C)(C)
[NH2+]CC(C1=CC(=CC(=C1)O)O)O.[O-]S(=O)(=O)[O-
| Formula =(C<sub>12</sub>H<sub>20</sub>NO<sub>3</sub>)<sub>2</sub> SO<sub>4</sub>
| MolarMass = 548.6468
| Metabolism = GI tract (oral), liver; CYP450: unknown
| Half_life = urine 90% (60% unchanged), bile/faeces; Half-life: 3-4h
| Pregnancy_cat = B
| Legal_status = [http://en.wikipedia.org/wiki/Prescription_drug POM]
| Routes = SQ, Oral, Inhaled
}}
<noinclude>[[Image:Bricanyl_Terbutaline_sulphate.JPG|center|350px|Bricanyl terbutaline sulphate inhaler]]
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Terbutaline sulphate belongs to a class of drugs known as [http://en.wikipedia.org/wiki/Beta2-adrenergic_receptor_agonist short acting beta 2 agonists]. It is a [http://en.wikipedia.org/wiki/Bronchodilator bronchodilator] These drugs work by acting on the lungs' beta 2 receptors. Stimulation of these recpetors cause the relaxation of muscles in the airway, thus allowing the opening of the airway. Terbutaline sulphate is used in the treatment of conditions that cause the narrowing of airways such as [http://en.wikipedia.org/wiki/Asthma asthma], [http://en.wikipedia.org/wiki/Bronchitis bronchitis] and [http://en.wikipedia.org/wiki/Emphysema emphysema]. Terbutaline sulphate is mainly administered as an inhaler, where the drug can directly get to the lungs. It can also be taken in tablet form if the inhaler is being used frequently to ease shortness of breath. The tablets can be taken regularly to help keep the airways constantly open and reduce inhaler usage. However the inhaler has the advantage of reducing the chance of side effects occuring in other body parts, as the quantity of the drug absorbed by the blood via inhalation is smaller than the quantity taken orally.<ref>http://www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100002557.html</ref>

==Conditions where the drug is used==
[http://en.wikipedia.org/wiki/COPD Chronic obstructive pulmonary disease] (COPD)

[http://en.wikipedia.org/wiki/Bronchospasm Bronchospasm] (narrowing of the airways) in other lung conditions (e.g. bronchitis and emphysema)

Asthma <ref>http://www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100002557.html</ref>

==Side Effects==
Chest discomfort

Breathing difficulty

Dizziness

Drowsiness

Fast, irregular heartbeat

Headache

Increased heart rate

Nausea

Sweating

Tremors

Weakness <ref>http://www.drugs.com/pdr/terbutaline-sulfate.html</ref>

==Synthesis==
To synthesise terbutaline sulphate, first terbutaline needs to be formed from the parent [http://en.wikipedia.org/wiki/Cyanohydrin cyanohydrin]. This done via a [http://en.wikipedia.org/wiki/Ritter_reaction Ritter reaction] to convert the [http://en.wikipedia.org/wiki/Nitrile nitrile] group into an N-alkyl [http://en.wikipedia.org/wiki/Amide amide]. <ref>Synthesis of the Adrenergic Bronchodilators (R)-Terbutaline and (R)-Salbutamol from (R)-Cyanohydrins1
Effenberger, F.; Jager, J.
J. Org. Chem.; (Article); 1997; 62(12); 3867-3873. DOI: 10.1021/jo970032d </ref>

When the N-alkyl amide has been made; treat with [http://en.wikipedia.org/wiki/Sulphuric_acid sulphuric acid] to make terbutaline sulphate.

[[Image:Synthesis.png|center|350px|synthesis of terbutaline sulphate]]

==References==

<references/>

File:Bricanyl Terbutaline sulphate.JPG

2007-10-29T16:18:09Z

Mr406:

File:Bricanyl terbutaline sulphate.JPG

2007-10-29T16:16:40Z

Mr406:

2007-10-29T14:15:59Z

Mr406:

==Terbutaline Sulphate==
{{Drug-Box |
| Box_Name = Terbutaline Sulphate
| ImageFile = Terbutaline_sulphate.png
| IUPACName = tert-butyl-[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]azanium sulfate
| OtherName = Bricanyl
| CAS_No = {{{23031-32-5}}}
| ATC_Code = [http://www.whocc.no/atcddd/indexdatabase/index.php?query=R03AC03 R03AC03][http://www.whocc.no/atcddd/indexdatabase/index.php?query=R03CC03 R03CC03]
| PubChem = 36120
| SMILES = CC(C)(C)[NH2+]CC(C1=CC(=CC(=C1)O)O)O.CC(C)(C)
[NH2+]CC(C1=CC(=CC(=C1)O)O)O.[O-]S(=O)(=O)[O-
| Formula =(C<sub>12</sub>H<sub>20</sub>NO<sub>3</sub>)<sub>2</sub> SO<sub>4</sub> C24H40N2O10S
| MolarMass = 548.6468
| Metabolism = GI tract (oral), liver; CYP450: unknown
| Half_life = urine 90% (60% unchanged), bile/faeces; Half-life: 3-4h
| Pregnancy_cat = B
| Legal_status = [http://en.wikipedia.org/wiki/Prescription_drug POM]
| Routes = SQ, Oral, Inhaled
}}
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Terbutaline sulphate belongs to a class of drugs known as [http://en.wikipedia.org/wiki/Beta2-adrenergic_receptor_agonist short acting beta 2 agonists]. It is a [http://en.wikipedia.org/wiki/Bronchodilator bronchodilator] These drugs work by acting on the lungs' beta 2 receptors. Stimulation of these recpetors cause the relaxation of muscles in the airway, thus allowing the opening of the airway. Terbutaline sulphate is used in the treatment of conditions that cause the narrowing of airways such as [http://en.wikipedia.org/wiki/Asthma asthma], [http://en.wikipedia.org/wiki/Bronchitis bronchitis] and [http://en.wikipedia.org/wiki/Emphysema emphysema]. Terbutaline sulphate is mainly administered as an inhaler, where the drug can directly get to the lungs. It can also be taken in tablet form if the inhaler is being used frequently to ease shortness of breath. The tablets can be taken regularly to help keep the airways constantly open and reduce inhaler usage. However the inhaler has the advantage of reducing the chance of side effects occuring in other body parts, as the quantity of the drug absorbed by the blood via inhalation is smaller than the quantity taken orally.

==Conditions where the drug is used==
[http://en.wikipedia.org/wiki/COPD Chronic obstructive pulmonary disease] (COPD)

[http://en.wikipedia.org/wiki/Bronchospasm Bronchospasm] (narrowing of the airways) in other lung conditions (e.g. bronchitis and emphysema)

Asthma

==Side Effects==
Chest discomfort

Breathing difficulty

Dizziness

Drowsiness

Fast, irregular heartbeat

Headache

Increased heart rate

Nausea

Sweating

Tremors

Weakness

==Synthesis==
To synthesise terbutaline sulphate, first terbutaline needs to be formed from the parent [http://en.wikipedia.org/wiki/Cyanohydrin cyanohydrin]. This done via a [http://en.wikipedia.org/wiki/Ritter_reaction Ritter reaction] to convert the [http://en.wikipedia.org/wiki/Nitrile nitrile] group into an N-alkyl [http://en.wikipedia.org/wiki/Amide amide].

When the N-alkyl amide has been made; treat with [http://en.wikipedia.org/wiki/Sulphuric_acid sulphuric acid] to make terbutaline sulphate.
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